Tetrapyrroles and derivatives
Apexbio Technology LLC Hematoporphyrin dihydrochloride 17696-69-4 100mg
Hematoporphyrin dihydrochloride (CAS 17696-69-4) is a porphyrin-based photosensitizer utilized in biomedical research Upon exposure to specific wavelengths of light it generates reactive oxygen species that induce apoptosis in cancer cells as demonstrated in U87 glioma cell models In vivo studies indicate that hematoporphyrin dihydrochloride suppresses tumor progression This compound also serves as a substrate in heme-binding protein affinity chromatography supporting protein interaction studies Its primary research applications include the investigation of tumor cell apoptosis mechanisms and the evaluation of photodynamic therapy strategies
Sigma Aldrich Fine Chemicals Biosciences Hemin BioXtra from Porcine5G
REAGENT Hemin BioXtra from Porcine5G
Abcam Zaprinast, cGMP phosphodiesterase inhibitor, 50MG
MW 271.28 g/mol, Purity >98%. Specific cGMP phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15 (PDE6), 0.76 (PDE5), 12 (PDE11) and 29 μM (PDE9)). Reputed GPR35 agonist (EC₅₀ values are 16 and 840 nM at rat and human GPR35 receptors, respectively). Important mediator for a variety of cellular processes including vasodilation.
The product is subject to the following: Abcam Restricted Use Statement
Frontier Specialty Chemicals 5G CO(II) MESO-TETRA (4-METHOX
Co(II) meso-Tetra (4-methoxyphenyl) Porphine (1-3% chlorin); CAS: 28903-71-1; 5g
Frontier Specialty Chemicals 25G CO(II) MESO-TETRA (4-METHO
Co(II) meso-Tetra (4-methoxyphenyl) Porphine (1-3% chlorin); CAS: 28903-71-1; 25g
Abcam 5-Aza-2'-deo x ycytidine (Decitabine), DNMT1 inhibitor, 10MG
MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC₅₀ = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam x estospongin C, IP3 receptor antagonist, 50UG
MW 446.72 g/mol, Purity >90%. Potent, selective, reversible IP₃ receptor antagonist (IC₅₀ = 350 nM). Inhibits IP₃-mediated Ca²+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca²+ and K+ channels at higher concentrations. Cell-permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 5MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
Abcam x estospongin C, IP3 receptor antagonist, 10UG
MW 446.72 g/mol, Purity >90%. Potent, selective, reversible IP₃ receptor antagonist (IC₅₀ = 350 nM). Inhibits IP₃-mediated Ca²+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca²+ and K+ channels at higher concentrations. Cell-permeable.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC Tin protoporphyrin IX
Tin Protoporphyrin IX dichloride is a potent inhibitor of heme oxygenase-1 (HO-1) reduces ozone-induced pulmonary inflammation and BAL cell necrosis highlighting its protective role It also sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in a mouse model suggesting its potential for PDAC treatment
Apexbio Technology LLC Tin protoporphyrin IX dichloride(Synonyms: Tin Protoporphyrin Dichloride, SnPP, SnPP IX, Tin(IV) Protoporphyrin Dichloride), 25mg, CAS: 14325-05-4.
Tin protoporphyrin IX dichloride (CAS 14325-05-4) is a synthetic metalloporphyrin analog that selectively inhibits heme oxygenase-2 (HO-2) an enzyme abundant in neuronal and endothelial tissues responsible for catalyzing heme breakdown into biliverdin and carbon monoxide (CO) It shows selectivity for HO over endothelial nitric oxide synthase and soluble guanylyl cyclase with IC50 values of 35 and 30 nM respectively In rat neonates administration of this compound suppresses the physiological increase in HO activity post-birth and prevents neonatal hyperbilirubinemia demonstrating utility in biomedical research on heme metabolism pathways
Abcam Prodigiosin, apoptotic agent, 1MG
MW 323.4 Da, Purity >95%. Potent apoptotic agent. Antibiotic agent. Induces caspase-dependent apoptosis. Inhibits mTORC1 and mTORC2. Reactivates p53. Inhibits iNOS expression. Shows anti-ischemic and antimalarial effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam Phomo x anthone A, apoptotic agent, 1MG
MW 750.7 Da, Purity >97%. Cancer cell selective apoptotic agent. Antibiotic agent. Induces apoptosis in cancer cells lines with 100 fold greater potency than noncancerous lines. Shows immunostimulant effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (R)-CPP (mM/ml), NMDA antagonist, 10MM_ML
MW 252.2 Da. Highly potent, competitive NMDA antagonist; more active enantiomer of (RS)-CPP (ab120160). (Ki values are 0.04, 0.3, 0.6 and 2.0 μM at NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D, respectively).
The product is subject to the following: Abcam Restricted Use Statement